Resolution:
Yes, there are two ways to do it. One way is to create an Administrative Group, which is a logical grouping of multiple user profiles. In fact, a given user can be present in multiple administative groups (maybe one based on his/her department and another based on his/her physical endpoint). Configuration changes can be applied at the group level. The MXM is also intelligent enough to only show configuration settings that are in common with every member of the group.

Another method is to use Ctrl + Mouse Click or Shift + Mouse Click to highlight several endpoints at once then make changes.